Schizophrenia Gene Expression Profile Reverted to Normal Levels by Antipsychotics
نویسندگان
چکیده
منابع مشابه
Schizophrenia Gene Expression Profile Reverted to Normal Levels by Antipsychotics
BACKGROUND Despite the widespread use of antipsychotics, little is known of the molecular bases behind the action of antipsychotic drugs. A genome-wide study is needed to characterize the genes that affect the clinical response and their adverse effects. METHODS Here we show the analysis of the blood transcriptome of 22 schizophrenia patients before and after medication with atypical antipsyc...
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Antipsychotic drugs are one of the largest types of prescribed drugs and have large inter-individual differences in efficacy, but there is no methodology to predict their clinical effect. Here we show a four-gene blood expression profile to predict the response to antipsychotics in schizophrenia patients before treatment. We sequenced total mRNA from blood samples of antipsychotic naïve patient...
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OBJECTIVE Metabolic abnormalities, e.g., diabetes, are common among schizophrenia patients. Peroxisome proliferator activated receptor-γ (PPAR-γ) regulates glucose/lipid metabolisms, and schizophrenia like syndrome may be induced by actions involving retinoid X receptor-α/PPAR-γ heterodimers. We examined a possible role of the PPAR-γ gene in metabolic traits and psychosis profile in schizophren...
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PURPOSE The retinoblastoma gene (RB1) is a tumor suppressor gene that was first discovered in a rare ocular pediatric tumor called retinoblastoma (RB). The RB1 gene is essential for normal progression through the cell cycle and exerts part of its function through the family of transcription factors (E2F) and many other intermediaries. In the absence of normal RB1, genomic instability and chromo...
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ژورنال
عنوان ژورنال: International Journal of Neuropsychopharmacology
سال: 2015
ISSN: 1469-5111,1461-1457
DOI: 10.1093/ijnp/pyu066